产品管线
开创新一代疗法，为健康生活加码
产品管线
免疫
肿瘤/肿瘤免疫
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项目(合作方)靶点适应症地区早期发现临床前IND一期二期三期BLA
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HBM4003
CTLA-4
黑色素瘤, 肝细胞癌, 肾细胞癌及其他晚期实体瘤
黑色素瘤, 肝细胞癌, 神经内分泌肿瘤/癌及其他晚期实体瘤
晚期非小细胞肺癌及其他晚期实体瘤
全球
全球
全球
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HBM7022
Claudin18.2xCD3
实体瘤
全球许可授权给阿斯利康
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HBM1007
CD73
实体瘤
全球
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HBM7020
BCMAxCD3
多发性骨髓瘤
大中华区以外
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HBM7008
B7H4x4-1BB
实体瘤
全球
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HBM1022
CCR8
实体瘤
全球
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HBM1020
B7H7
实体瘤
全球
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和铂医药
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合作方
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注册临床实验
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单一疗法
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PD1 / 化疗
大中华区权益已授权华兰基因
科学论文和报告
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A New Generation of Fully Human anti-CTLA-4 Heavy Chain Only Antibody
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BCMA x CD3 Bispecific Antibody – A novel HBICE™-based Molecule with Efficient Tumor Killing and Minimal Cytokine Release
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HBM1007 – A Highly Potent Anti-CD73 mAb Candidate For Mono And Combination IO Therapy
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Novel Monoclonal Antibodies (mAbs) Targeting Human CCR8 Provide Potential Candidates for Next Generation Cancer Immunotherapy
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HBM1022, a Novel Anti-CCR8 Antibody, Depletes Tumor-infiltrating Regulatory T cells via Enhanced ADCC Activity, Mediates Potent Anti-Tumor Activity
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HCAb Based Bispecific Immune Cell Engager (HBICE) Platform Enables Fast And Convenient Generation of the Next Generation Bispecific Antibodies with High Potency, Promising Safety Profiles and Excellent Developability
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Discovery of potent and functional human antibodies against a new B7-family member, B7H7, for cancer immunotherapy
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Development of fully human T-cell engaging bispecific antibodies targeting B7H4
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Preclinical evaluation of HBM7022, an HBICE™ 2+1 CLDN18.2 x CD3 bispecific antibody, for gastric cancer
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Cell Engager Summit Exclusive Speaker Interview
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Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein
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A human monoclonal antibody blocking SARS-CoV-2 infection
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Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes
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A conserved immunogenic and vulnerable site on the coronavirus spike protein delineated by cross-reactive monoclonal antibodies
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SARS-CoV-2 Neutralizing Human Antibodies Protect Against Lower Respiratory Tract Disease in a Hamster Model
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Safety, tolerability, pharmacokinetics, and pharmacodynamics of HBM9161, a novel FcRn inhibitor, in a phase I study for healthy Chinese volunteers
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Therapeutic Response and Possible Biomarkers in Acute Attacks of Neuromyelitis Optica Spectrum Disorders: A Prospective Observational Study
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TNF-α inhibitor tanfanercept (HBM9036) improves signs and symptoms of dry eye in a phase 2 trial in the controlled adverse environment in China
